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Home > EN > Research Areas > Nonlinear Dynamics of Optical and Biological Systems > BIological Systems > Cell cycle and differentiation

Cell cycle and differentiation

by Benjamin PFEUTY - published on , updated on


Living cells often alternate between proliferation and differentiation states as part of individual or collective strategies to adapt to complex and ever-changing environments. This is especially the case in multicellular organisms that requires a precise spatio-temporal control of cell fate (quiescence, division, differentiation or death) to achieve proper tissue development and homeostasis. The aim is to better understand the regulatory logic of cell-fate decisions at single- and multi-cell levels, and a dynamical modeling approach is used to address a variety of related issues :

- Plasticity of the cell-division cycle
- Coordination of proliferation and differentiation in stem cells
- Network and dynamical mechanisms underlying cellular decision-making

Publications

- Pfeuty B etal, Underlying principles of cell fate determination during G1 phase of the mammalian cell cycle, Cell Cycle, 7, 3246, 2008.
- Pfeuty B and Kaneko K, The combination of positive and negative feedback loops confers exquisite flexibility to biochemical switches, Phys. Biol. 6, 046013, 2009
- Pfeuty B etal, A dynamical model of oocyte maturation unveils precisely orchestrated meiotic decisions, PLoS Comput. Biol. 8, e1002329, 2012.
- Pfeuty B, Strategic cell-cycle regulatory features that provide mammalian cells with tunable G1 length and reversible G1 arrest,PLoS One 7, 0035291, 2012.
- Pfeuty B, Dynamical principles of cell-cycle arrest: reversible, irreversible, and mixed strategies, Phys Rev E, 86, 021917, 2012.
- Pfeuty B and Kaneko K, Binary cell fate decision based on oscillations, Phys Rev E 89, 022707, 2014.
- Pfeuty B, A computational model of the coordination of neural progenitor self-renewal and differentiation through the Hes1 dynamics, Development 142, 477-85, 2015.
- Pfeuty B. Neuronal specifications exploit the inherent flexibility of cell-cycle gap phases, Neurogenesis 2, e1095694, 2015.
- Pfeuty B, Kaneko K Requirements for efficient cell-type proportioning, Phys Biol, 2016.

Collaborations

- T. David-Pfeuty, J.F. Bodart (Univ. of Lille 1), K. Kaneko (Univ. of Tokyo)
- B. Pain, C. Kress (Stem-cell and Brain Research Institute)

Offer

- Postdoc offer available on these topics. Please contact :
- Benjamin PFEUTY (Benjamin.PFEUTY@univ-lille1.fr)